Biopharmaceutics of 13-cis-retinoic acid (isotretinoin) formulated with modified β-cyclodextrins
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منابع مشابه
The Effects of Oral Isotretinoin (13-Cis Retinoic Acid) on the Inner Ear: A Clinical Study
Materials and Methods: Twenty-five patients (50 ears) with acne vulgaris who were treated with isotretinoin 5mg/kg were included in this study. Two patients gave up using isotretinoin after two months. Pure tone audiometry, TEOAE and DPOAE were evaluated before the use of isotretinoin and after 4 months of treatment. DPOAE was recorded as a DPgram. Results: Pre-treatment and post-treatment pure...
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PURPOSE To investigate the feasibility of adaptive dosing and the impact of pharmacogenetic variation on 13-cis-retinoic acid (13-cisRA) disposition in high-risk patients with neuroblastoma. EXPERIMENTAL DESIGN 13-cisRA (160 mg/m(2) or 5.33 mg/kg/d) was administered to 103 patients ages 21 years or less and plasma concentrations of 13-cisRA and 4-oxo-13-cisRA quantitated on day 14 of treatmen...
متن کاملChronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats.
Oral treatment with the anti-acne drug Accutane (isotretinoin, 13-cis-retinoic acid) has been associated with suicide ideation and depression. Here, depression-like behaviors (i.e., behavioral despair and anhedonia) were quantified in adult Sprague-Dawley rats gavaged daily beginning at postnatal day (PND) 82 with 13-cis-RA (7.5 or 22.5 mg/kg) or all-trans-retinoic acid (10 or 15 mg/kg ). Teste...
متن کاملPharmacology of 13-cis-retinoic acid in humans.
Vitamin A and its analogs (retinoids) have shown great promise for the chemoprevention of cancer as well as being a possible new class of chemotherapeutic agents. A Phase I and II trial of 13-cis-retinoic acid in advanced cancers was initiated, and the clinical pharmacology of the drug was studied. All patients received p.o. 13-cis-retinoic acid starting at 0.5 mg/kg/day, escalating over 4 week...
متن کاملThe effects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: a prospective clinical study.
PURPOSE The purpose of this study was to investigate the effect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations. METHODS Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. The hearing of each participant was tested with ...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2007
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2007.03.050